In ancient roman times the water are famous for their reputed healing properties and ability to cure diseases and were believed especially helpful in mending broken bones. The waters were both used for bathing and drinking as a tonic.
Several dedicatory inscriptions in honour of the waters have been found: the waters themselves were honoured as "Aquae Albulae Sanctissimae", especially by Strabo and Pliny the Elder.

After the glory known in imperial period, the Baths of Agrippa were slowly forgotten. The Acquae Albule were allowed free play from the first barbaric invasion up to the sixteenth centuiry, when Cardinal Ippolito II d'Este gathered them again into the channel which takes its name from him, and which nowadays is in use.

In modern times most of its waters are diverted to the modern Terme, not far from where the ancient roman baths were: the waters are still used today for bathing, in treating bone diseases; the fumes are breathed in as a cure for lung problems.